|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
1989-5-24
|
|
pubmed:abstractText |
An osteoblast calcium channel demonstrated by single channel recordings is associated with calcium antagonist receptor binding sites in osteoblast-like osteosarcoma cells. By using whole cell current recordings we now show that this channel is stimulated by the dihydropyridine calcium agonist drug BAY K 8644. A physiological relevance of these channels is apparent from the stereoselective, potent inhibition of parathyroid hormone-stimulated calcium uptake into osteoblast-like cells in culture by desmethoxyverapamil, a phenylalkylamine calcium antagonist. Secretion by these cells of the bone matrix protein osteocalcin is stimulated by BAY K 8644 and blocked by desmethoxyverapamil and nitrendipine. Evidence for a role of this channel in bone remodeling in intact animals comes from enhanced bone resorption in fetal rat bones observed with BAY K 8644 and stereoselective, potent blockade of resorption by desmethoxyverapamil.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-14254246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-2410796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-2438281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-2454047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-2455711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-2841959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-2854310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-2994886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3012067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3028378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3194015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3281002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3511389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3520321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3632719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-3859011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-4316955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-4392630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6094965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6177951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6207437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6322304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6333574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6936260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6968673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2468165-6969260
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
86
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2957-60
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2468165-3-Pyridinecarboxylic acid...,
pubmed-meshheading:2468165-Animals,
pubmed-meshheading:2468165-Bone Development,
pubmed-meshheading:2468165-Bone Resorption,
pubmed-meshheading:2468165-Calcium,
pubmed-meshheading:2468165-Calcium Channels,
pubmed-meshheading:2468165-Calcium-Binding Proteins,
pubmed-meshheading:2468165-Cells, Cultured,
pubmed-meshheading:2468165-Dihydropyridines,
pubmed-meshheading:2468165-Electric Conductivity,
pubmed-meshheading:2468165-Osteoblasts,
pubmed-meshheading:2468165-Osteocalcin,
pubmed-meshheading:2468165-Parathyroid Hormone,
pubmed-meshheading:2468165-Rats,
pubmed-meshheading:2468165-Receptors, Nicotinic,
pubmed-meshheading:2468165-Stereoisomerism
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Bone remodeling signaled by a dihydropyridine- and phenylalkylamine-sensitive calcium channel.
|
|
pubmed:affiliation |
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|
