Linked Life Data

2467977

Source:http://linkedlifedata.com/resource/pubmed/id/2467977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-5-12
pubmed:abstractText
Antinociceptive effects of baclofen, a gamma-aminobutyric acidB (GABAB) agonist, were studied in mice along with other GABAergic agents, all administered intrathecally (i.t.): i.e., muscimol (GABAA agonist), bicuculline (GABAA antagonist) and 5-aminovaleric acid (GABAB antagonist). After i.t. administration, none of the four compounds increased the withdrawal latency in the tail-flick test. With the intradermal hypertonic saline (6% saline) behavioral test, baclofen decreased the number of behaviors in a dose-dependent and 5-aminovaleric acid-reversible manner, whereas i.t. administered muscimol was ineffective. With the i.t. substance P (SP) behavioral test, muscimol was again ineffective, whereas the SP-induced behaviors were differentially modified by baclofen depending on the temporal order of their i.t. administration. Although baclofen, coadministered with SP, decreased the number of SP-induced behaviors, baclofen pretreatment (2-100 min before i.t. administration of SP) increased the number of behaviors in a dose-dependent and 5-aminovaleric acid-reversible manner. Two minutes after several fixed doses of baclofen were administered i.t., dose-response curves for induction of behaviors by SP (i.t.) were shifted progressively to the left by increasing doses of baclofen, suggesting that hypersensitivity to SP had developed during this time frame. Decreased responsiveness to a peripheral noxious stimulus (hypertonic saline-induced behavior) is therefore associated with hypersensitivity to i.t. applied SP (SP behavioral test). The selective action of a GABAB agonist on neurokinin-elicited behaviors shown in this study is in clear contrast to the selective action of a GABA agonist against excitatory amino acid spinal activity noted in the following paper.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
248
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1026-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Baclofen, gamma-aminobutyric acidB receptors and substance P in the mouse spinal cord.
pubmed:affiliation
Department of Pharmacology, University of Minnesota Medical School, Minneapolis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't