Linked Life Data

2467888

Source:http://linkedlifedata.com/resource/pubmed/id/2467888

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-5-15
pubmed:abstractText
A conjugate of mitomycin C and the mannan of bakers' yeast (Saccharomyces cerevisiae wild type strain) was synthesized. Assay of its growth inhibitory effect on MH134 hepatoma solid tumor implanted in C3H/He slc mice showed that this conjugate exhibited a higher growth-inhibition ratio than those of free mitomycin C and the same bakers' yeast mannan in the corresponding effective doses. This conjugate was also found to kill the same hepatoma cells in vitro. Because a dextran-mitomycin C conjugate did not manifest any antitumor effect against this tumor, it was postulated that interaction of the mannan moiety in the mannan-mitomycin C conjugate with the mannose receptor located on the cell surface of immunocytes and/or with hepatoma cells participated in the common initiating reaction of in vitro and in vivo antitumor effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0192-0561
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Antitumor effect of a baker's yeast mannan-mitomycin C conjugate against mouse hepatoma, MH134, in vivo and in vitro.
pubmed:affiliation
Department of Microbiology, Tohoku College of Pharmacy, Miyagi, Japan.
pubmed:publicationType
Journal Article