rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1989-4-17
|
pubmed:abstractText |
1- Anti-liver/kidney microsome autoantibodies type 1 (anti-LKM1), observed in some children with chronic active hepatitis, were used to isolate their antigen in human liver microsomes. A protein, called P-LKM1 was thus purified. This protein was recognized by a rabbit antiserum directed against the related human cytochromes P-450 bufI and P-450 bufII. 2- A human liver microsomal protein immunoprecipitated with anti-LKM1 sera was also recognized by anti cytochromes P-450 bufI/II antibodies. 3- Anti-LKM1 antibodies potently inhibited microsomal bufuralol 1'-hydroxylation. These results displayed the possible identity between cytochrome P-450 bufI/II and LKM1 antigen.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0006-291X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
28
|
pubmed:volume |
159
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
283-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2466461-Autoantibodies,
pubmed-meshheading:2466461-Autoantigens,
pubmed-meshheading:2466461-Autoimmune Diseases,
pubmed-meshheading:2466461-Cytochrome P-450 Enzyme System,
pubmed-meshheading:2466461-Epitopes,
pubmed-meshheading:2466461-Fluorescent Antibody Technique,
pubmed-meshheading:2466461-Hepatitis, Chronic,
pubmed-meshheading:2466461-Humans,
pubmed-meshheading:2466461-Immunoblotting,
pubmed-meshheading:2466461-Immunosorbent Techniques,
pubmed-meshheading:2466461-Isoenzymes,
pubmed-meshheading:2466461-Kidney,
pubmed-meshheading:2466461-Microsomes,
pubmed-meshheading:2466461-Microsomes, Liver
|
pubmed:year |
1989
|
pubmed:articleTitle |
A human cytochrome P-450 is recognized by anti-liver/kidney microsome antibodies in autoimmune chronic hepatitis.
|
pubmed:affiliation |
INSERM U 75, CHU Necker-Enfants Malades, Paris.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|