Linked Life Data

2465439

Source:http://linkedlifedata.com/resource/pubmed/id/2465439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-4-5
pubmed:abstractText
The effect of intravenous and intrapericardial administration of verapamil on cardiac reflexes was studied in chloralose-anesthetized cats. Cardiac reflexes were induced by either intrapericardial application of serotonin (80 micrograms/kg) and dimethylphenylpiperazinium iodide (DMPP) (20 micrograms/kg) or by occlusion of the ascending aorta for 30 s. Intrapericardial application of verapamil (3 and 6 micrograms/kg) did not change the epicardial chemoreflexes, whereas intravenous administration of verapamil in the normal clinical dose enhanced the cardiac reflexes induced by chemical or mechanical stimulation. These results indicate that verapamil does not act directly on the vagal afferent nerve fibers in the epicardium of the heart. We suggest that the augmentation of cardiac reflexes by verapamil might be caused by an action of verapamil on the sinoaortic baroreflex or baroreceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-404
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Augmentation of cardiac reflexes in the cat by the calcium antagonist verapamil.
pubmed:affiliation
Department of Cardiovascular Physiology, University of Düsseldorf, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't