Linked Life Data

2464947

Source:http://linkedlifedata.com/resource/pubmed/id/2464947

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1989-3-23
pubmed:abstractText
Peripheral and central effects of acute and chronic immobilization stress were measured in lean and obese Zucker female rats. Thus hypothalamic serotonergic metabolism was analyzed by measuring the concentrations of serotonin (5-hydroxytryptamine, 5-HT), tryptophan (TRP; the precursor of 5-HT), and 5-hydroxyindoleacetic acid (5-HIAA; 5-HT metabolite). In addition, plasma total TRP, free fatty acid (FFA), insulin, and corticosterone concentrations were measured. Analysis of stress-induced changes in food consumption were also included. A single 2-h restraint stress was found to increase TRP availability in the hypothalamus of both rats; this promoted an increase in 5-HIAA in the lean rats and increases in 5-HT and 5-HIAA in the obese (fa/fa) rats. These modifications were associated with marked decreases in plasma total TRP and insulinemia in the lean and obese rats. Whereas stress triggered similar hypercorticosteronemia and hyperglycemia, FFA was increased in the lean rats only. Consecutive hypophagia was noted in all the rats. Twenty-four hours after the last of the four 2-h stress sessions, hypothalamic 5-HIAA was increased in the obese rats and plasma TRP and FFA levels decreased in both rats. Although both groups of rats were normoglycemic, stress-induced hyperinsulinemia was evidenced in the lean rats, thus suggesting that chronic stress promotes insulin resistance. These metabolic variations were associated with normal food consumption and increased body weight gains in the lean and obese Zucker rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R435-42
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Peripheral and central consequences of immobilization stress in genetically obese Zucker rats.
pubmed:affiliation
Laboratoire de Pharmacologie, Institut National de la Santé et de la Recherche Médicale U7, Centre Hospitalier Universitaire, Paris, France.
pubmed:publicationType
Journal Article