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rdf:type |
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lifeskim:mentions |
umls-concept:C0001640,
umls-concept:C0031939,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035668,
umls-concept:C0040168,
umls-concept:C0205359,
umls-concept:C0240526,
umls-concept:C0332120,
umls-concept:C0597295,
umls-concept:C1546857,
umls-concept:C1948023
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pubmed:issue |
2
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|
pubmed:dateCreated |
1989-3-23
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|
pubmed:abstractText |
Pineal thyroxine 5'-deiodinase (5'-D) activity rose greater than 10-fold above the basal level 2-3 hr after 1 mg/kg isoproterenol and returned to near the basal level by 6 hr. The same dose of norepinephrine or phenylephrine was without effect, but phenylephrine modestly potentiated isoproterenol-stimulated 5'-D activity. Either actinomycin D or cycloheximide treatment markedly decreased diurnal isoproterenol stimulation and the spontaneous rhythmic nocturnal rise of pineal 5'-D. The data indicate that pineal 5'-D activity is very similar to pineal serotonin N-acetyl transferase in being primarily stimulated by beta-adrenergic agonists and requiring new RNA and protein synthesis for its activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0037-9727
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
190-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2464832-Adrenergic alpha-Agonists,
pubmed-meshheading:2464832-Adrenergic beta-Agonists,
pubmed-meshheading:2464832-Animals,
pubmed-meshheading:2464832-Circadian Rhythm,
pubmed-meshheading:2464832-Cycloheximide,
pubmed-meshheading:2464832-Dactinomycin,
pubmed-meshheading:2464832-Drug Interactions,
pubmed-meshheading:2464832-Iodide Peroxidase,
pubmed-meshheading:2464832-Isoproterenol,
pubmed-meshheading:2464832-Kinetics,
pubmed-meshheading:2464832-Male,
pubmed-meshheading:2464832-Norepinephrine,
pubmed-meshheading:2464832-Phenylephrine,
pubmed-meshheading:2464832-Pineal Gland,
pubmed-meshheading:2464832-Protein Biosynthesis,
pubmed-meshheading:2464832-RNA,
pubmed-meshheading:2464832-Rats,
pubmed-meshheading:2464832-Rats, Inbred Strains
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pubmed:year |
1989
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pubmed:articleTitle |
Evidence that rat pineal thyroxine 5'-deiodinase is primarily stimulated by beta- and not alpha-adrenergic agonists and that its adrenergic-stimulated and spontaneous rhythmic nocturnal rise require RNA and protein synthesis.
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pubmed:affiliation |
Department of Medicine, Oregon Health Services University, Portland 97201.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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