Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1989-3-2
pubmed:abstractText
The ribosomal preparations of S. sonnei and some other bacterial species were obtained by the method of differential centrifugation, and the specificity of their protective action was studied in the keratoconjunctivitis test on guinea pigs. The ribosomal preparations were introduced parenterally in a single injection, and their protective action was determined two weeks later by the challenge of the animals with S. sonnei virulent strain and the subsequent calculation of the efficiency index (EI) by the formula: EI = C-V/C X 100, where C and V are the percentage of resistant eyes in the control and vaccinated groups of the animals respectively. For the ribosomal preparation obtained from a homologous avirulent strain this index was equal to 58%, while for the heterologous ribosomes obtained from Escherichia coli, Salmonella minnesota and S. flexneri in was close to zero. The ribosomal preparations obtained from S. sonnei R-strain which had no surface or cytoplasmic O-antigen also proved to be ineffective in rendering protection against local Shigella infection. The results of this investigation are compared with the data obtained by other authors, and the analysis of these results leads to the conclusion that the O-specific component is the indispensable factor of the protective activity of many ribosomal vaccines and its molecular properties require further study. The possible role of other components of the ribosomal vaccine is also discussed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0372-9311
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2464261-Animals, pubmed-meshheading:2464261-Antibodies, Bacterial, pubmed-meshheading:2464261-Bacterial Vaccines, pubmed-meshheading:2464261-Drug Evaluation, Preclinical, pubmed-meshheading:2464261-Dysentery, Bacillary, pubmed-meshheading:2464261-Epitopes, pubmed-meshheading:2464261-Escherichia coli, pubmed-meshheading:2464261-Guinea Pigs, pubmed-meshheading:2464261-Immunization, pubmed-meshheading:2464261-Keratoconjunctivitis, pubmed-meshheading:2464261-Mice, pubmed-meshheading:2464261-Mice, Inbred C57BL, pubmed-meshheading:2464261-Mice, Inbred CBA, pubmed-meshheading:2464261-Mutation, pubmed-meshheading:2464261-R Factors, pubmed-meshheading:2464261-Rabbits, pubmed-meshheading:2464261-Ribosomes, pubmed-meshheading:2464261-Salmonella, pubmed-meshheading:2464261-Shigella flexneri, pubmed-meshheading:2464261-Shigella sonnei
pubmed:year
1988
pubmed:articleTitle
[Specificity of the protective action of a ribosomal Shigella vaccine and the absence of activity in the ribosomes from R mutants].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract