rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1989-3-9
|
pubmed:abstractText |
The influence of extracellular calcium and magnesium ion concentrations upon 5-HT3 receptor-gated membrane currents in murine N1E-115 neuroblastoma cells has been studied under voltage-clamp conditions. A decrease in the concentration of either Ca2+ or Mg2+ from their standard values of 1.0 and 2.0 mM respectively augmented both the amplitude and duration of the 5-HT-induced current, whereas elevating the concentration of either divalent cation produced the opposite effect. Such modulation did not involve a change in the reversal potential of the response.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0014-2999
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
14
|
pubmed:volume |
151
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
491-5
|
pubmed:dateRevised |
2009-9-29
|
pubmed:meshHeading |
pubmed-meshheading:2463926-Animals,
pubmed-meshheading:2463926-Calcium,
pubmed-meshheading:2463926-Cations,
pubmed-meshheading:2463926-Cells, Cultured,
pubmed-meshheading:2463926-Ion Channels,
pubmed-meshheading:2463926-Magnesium,
pubmed-meshheading:2463926-Membrane Potentials,
pubmed-meshheading:2463926-Mice,
pubmed-meshheading:2463926-Neoplasms, Experimental,
pubmed-meshheading:2463926-Neuroblastoma,
pubmed-meshheading:2463926-Receptors, Serotonin
|
pubmed:year |
1988
|
pubmed:articleTitle |
Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells.
|
pubmed:affiliation |
Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, University of Dundee, U.K.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|