Linked Life Data

2463861

Source:http://linkedlifedata.com/resource/pubmed/id/2463861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1989-3-7
pubmed:abstractText
Kinetic analysis of ion channel recordings attempts to distinguish the number and lifetimes of channel molecular states. Most kinetic analysis assumes that the lifetime of each state is independent of previous channel history, so that open and closed durations are Markov processes whose probability densities are sums of exponential decays. An alternative approach assumes that channel molecules have many configurtions with widely varying lifetimes. Rates of opening and closing then vary with the time scale of observation, leading to fractal kinetics. We have examined kinetic behavior in two types of channels from human and avian fibroblasts, using a maximum likehood method to test the dependence of rates on observational time scale. For both channels, openings showed mixed fractal and Markov behavior, while closings gave mainly fractal kinetics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0008-4212
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
967-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Fractal and Markov behavior in ion channel kinetics.
pubmed:affiliation
Department of Physiology, University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't