Linked Life Data

2462052

Source:http://linkedlifedata.com/resource/pubmed/id/2462052

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-1-24
pubmed:abstractText
Monoclonal antibodies were raised by injecting mice with cultured bovine, porcine or human vascular endothelial cells, and tested in an in vitro model of endothelial damage and regrowth. Antibodies were identified which produced four distinct and reproducible immunoperoxidase staining patterns, and these were further characterized by Western blotting and I125 labelling. Antibodies which recognize damaged endothelial cells probably do so by reacting with intracellular antigens made accessible by increased membrane permeability. Other antibodies give a diffuse staining of intact cells, by reacting with a membrane component, or a "negative stain" pattern by reacting with extracellular matrix material. A small number of antibodies recognize new or spreading endothelium perhaps by recognizing selectively expressed antigens on these cells. Appropriate monoclonal antibodies may be useful in studying endothelial behaviour in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0141-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Monoclonal antibodies to damaged and regenerating vascular endothelium.
pubmed:affiliation
Department of Medicine, University of Edinburgh, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't