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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1988-12-9
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pubmed:abstractText |
Fragments of the human immunodeficiency virus (HIV) envelope coding region have been fused with the hepatitis B virus envelope middle protein. In this system, HIV antigenic determinants are exposed at the surface of a highly antigenic structure, the hepatitis B surface antigen particle. Immunization of rabbits with these particles elicited antibodies directed against both parts of the hybrid protein. One of the rabbit antisera not only exhibited a neutralizing effect on the original HIV1 isolate but also on a divergent Zairian isolate. The HIV sequence in this recombinant is 84 amino acids long and contains conserved and variable domains and a region critical for interaction with the CD4 receptor. Such recombinant antigens could be primary elements in the design of a polyvalent vaccine.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-225559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2423250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2424612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2425034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2425433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2431482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2438696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2440037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2441877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2442253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2984774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2986290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-2995835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-3001934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-3014647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-3018753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-3094962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-3466790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-6096851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-6188163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-6200931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-6203528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-6323244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-6323254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-6933469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2460859-9279398
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7957-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2460859-Animals,
pubmed-meshheading:2460859-Antibody Formation,
pubmed-meshheading:2460859-Base Sequence,
pubmed-meshheading:2460859-Epitopes,
pubmed-meshheading:2460859-HIV Antibodies,
pubmed-meshheading:2460859-Hepatitis B Surface Antigens,
pubmed-meshheading:2460859-Humans,
pubmed-meshheading:2460859-Immune Sera,
pubmed-meshheading:2460859-Molecular Sequence Data,
pubmed-meshheading:2460859-Rabbits,
pubmed-meshheading:2460859-Recombinant Proteins,
pubmed-meshheading:2460859-Transfection
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pubmed:year |
1988
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pubmed:articleTitle |
Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV--hepatitis B surface antigen particles.
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pubmed:affiliation |
Unité de Recombinaison et Expression Génétique, Institut National de la Santé et de la Recherche Médicale Unité 163, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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