Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions |
umls-concept:C0006685,
umls-concept:C0024660,
umls-concept:C0030956,
umls-concept:C0056262,
umls-concept:C0332324,
umls-concept:C0501385,
umls-concept:C0598352,
umls-concept:C0871261,
umls-concept:C1267092,
umls-concept:C1280500,
umls-concept:C1513492,
umls-concept:C1704632,
umls-concept:C1705994,
umls-concept:C1706817,
umls-concept:C1709060,
umls-concept:C1879547,
umls-concept:C2911692
|
pubmed:issue |
2
|
pubmed:dateCreated |
1988-12-21
|
pubmed:abstractText |
1. The effect of omega-conotoxin (CTX) GVIA, a peptide which blocks neuronal calcium channels, were investigated on nerve-mediated motor responses in a variety of isolated smooth muscle preparations from rats and guinea-pigs. 2. In the rat or guinea-pig isolated vas deferens CTX (1 nM-1 microM) produced a concentration and time-related inhibition of the response to field stimulation, while the responses to KCl, noradrenaline or adenosine triphosphate were unaffected. In the presence of CTX a series of tetrodotoxin-resistant contractions could be elicited by field stimulation by increasing pulse width and/or voltage. 3. In the rat or guinea-pig isolated urinary bladder, CTX produced a concentration and time-dependent inhibition of twitch responses to field stimulation without affecting the response to exogenous acetylcholine. In the rat bladder the maximal effect did not exceed 25% inhibition while a much larger fraction of the response (about 70%) was inhibited in the guinea-pig bladder. The CTX-resistant response was abolished, in both tissues, by tetrodotoxin. 4. The effects of CTX in the rat bladder were also studied with a whole range of frequencies of field stimulation (0.1-50 Hz). Maximal inhibition was observed toward contractions elicited at frequencies of 2-5 Hz. At low frequencies the inhibitory effects of CTX and atropine were almost additive while at high frequencies of stimulation a large component of the atropine-sensitive response was CTX-resistant. 5. In the rat isolated proximal duodenum, field stimulation in the presence of atropine and guanethidine produced a primary relaxation followed by a rebound contraction.(ABSTRACT TRUNCATED AT 250 WORDS)
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Mollusk Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxin GVIA
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0028-1298
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
338
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
107-13
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2460772-Animals,
pubmed-meshheading:2460772-Calcium Channel Blockers,
pubmed-meshheading:2460772-Capsaicin,
pubmed-meshheading:2460772-Duodenum,
pubmed-meshheading:2460772-Guinea Pigs,
pubmed-meshheading:2460772-Male,
pubmed-meshheading:2460772-Mollusk Venoms,
pubmed-meshheading:2460772-Muscle, Smooth,
pubmed-meshheading:2460772-Muscle Contraction,
pubmed-meshheading:2460772-Neuroeffector Junction,
pubmed-meshheading:2460772-Neurons, Afferent,
pubmed-meshheading:2460772-Neurons, Efferent,
pubmed-meshheading:2460772-Rats,
pubmed-meshheading:2460772-Rats, Inbred Strains,
pubmed-meshheading:2460772-Substance P,
pubmed-meshheading:2460772-Urinary Bladder,
pubmed-meshheading:2460772-Vas Deferens,
pubmed-meshheading:2460772-omega-Conotoxin GVIA
|
pubmed:year |
1988
|
pubmed:articleTitle |
The effect of omega conotoxin GVIA, a peptide modulator of the N-type voltage sensitive calcium channels, on motor responses produced by activation of efferent and sensory nerves in mammalian smooth muscle.
|
pubmed:affiliation |
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
|
pubmed:publicationType |
Journal Article,
In Vitro
|