Linked Life Data

2460310

Source:http://linkedlifedata.com/resource/pubmed/id/2460310

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-12-16
pubmed:abstractText
A comparison of the ionic currents in single myelinated nerve fibres isolated from the sciatic nerve of the rat and the frog was performed. The nodal membrane of rats lacked almost totally potential dependent potassium channels, whereas in the frog large potassium currents were recorded. Therefore, it was concluded that in mammalian nerve fibres repolarization of the action potential is brought about by the unspecific leakage current and the inactivation of the sodium channels. Phenytoin and tocainide reduced the Na current in nerve fibres of both species. This reduction was due to a potential and frequency dependent block of sodium channels. 50 microM phenytoin and 200 microM tocainide shifted the inactivation curve of the sodium system by 25 mV to more hyperpolarizing membrane potentials. In addition, a decrease in the time interval between repetitive depolarizations increased the amount of Na current reduction. This suggested that in the presence of the drugs the equilibrium between resting and inactive sodium channel states was shifted to more inactivation. The results were successfully interpreted in terms of the "modulated receptor hypothesis".
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-7590
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Membrane currents and action potentials of myelinated nerve fibers and their modification by diphenylhydantoin and tocainide].
pubmed:affiliation
Physiologisches Institut, Universität Hamburg.
pubmed:publicationType
Journal Article, In Vitro, English Abstract