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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1988-12-1
|
| pubmed:abstractText |
Microtubule proteins, isolated by cycles of assembly, will undergo ATP-dependent gelation-contraction in vitro. A particulate component is present in these preparations, which is required for the gelation-contraction of microtubules assembled from purified tubulin. These particulates contain tubulin, neurofilament, spectrin, MAP2, and other as yet unidentified proteins. The particulates have a microtubule-stimulated ATPase that may be unique and is the likely motor for microtubule gelation-contraction. The basic structural unit of these particulates appears to be a crescent-shaped, or hemispherical, granule about 20 nm in diameter. The particles move along microtubule walls at a rate of about 1 micron. When compared to known physiological phenomena, microtubule gelation-contraction has striking similarities to component a of slow axonal transport (SCa), but displays no relationship to slow component b or to fast transport. On the basis of their similarities in composition, solubility, and rate of movement, we have proposed that the particulates responsible for microtubule gelation-contraction are the insoluble protein complexes, which have been suggested to be the transported component of SCa. We have termed these structures "slow component a particulates" or "SCAPs." It is probable that similar motile protein complexes exist in cells other than neurons, and we propose the term "dynasome" to describe such structures in general.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0886-1544
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
331-40
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2460260-Animals,
pubmed-meshheading:2460260-Axonal Transport,
pubmed-meshheading:2460260-Axons,
pubmed-meshheading:2460260-Cattle,
pubmed-meshheading:2460260-Microscopy, Electron,
pubmed-meshheading:2460260-Microtubule Proteins,
pubmed-meshheading:2460260-Microtubule-Associated Proteins,
pubmed-meshheading:2460260-Microtubules
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Microtubule gelation-contraction in vitro and its relationship to component a of slow axonal transport.
|
| pubmed:affiliation |
Department of Biology, Temple University, Philadelphia, PA 19122.
|
| pubmed:publicationType |
Journal Article
|