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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-11-21
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pubmed:databankReference |
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pubmed:abstractText |
The isolation and expression of a full-length cDNA clone encoding the B cell-specific glycoprotein CD19 is reported. The sequence of the cDNA predicts a glycosylated integral membrane protein with a precursor molecular weight of 51.8 x 10(3) and an extracellular domain organized into three contiguous Ig-like sub-domains. The cytoplasmic domain bears significant relatedness to two proteins encoded by the Epstein-Barr virus and the int-1 oncogene. CD19 transcripts are restricted to members of the B cell lineage, being most abundant in pre-B cell lines and least abundant in plasmacytomas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-2437199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-2437578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-2825196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-2959318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-2987520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-2998762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-3257143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-3714490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-6087149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-6408173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-6694911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-6806173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-6855599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2459292-6984001
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1205-10
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2459292-Amino Acid Sequence,
pubmed-meshheading:2459292-Antigens, CD19,
pubmed-meshheading:2459292-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:2459292-Base Sequence,
pubmed-meshheading:2459292-Blotting, Northern,
pubmed-meshheading:2459292-Cloning, Molecular,
pubmed-meshheading:2459292-DNA,
pubmed-meshheading:2459292-Humans,
pubmed-meshheading:2459292-Membrane Glycoproteins,
pubmed-meshheading:2459292-Molecular Sequence Data,
pubmed-meshheading:2459292-Molecular Structure
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pubmed:year |
1988
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pubmed:articleTitle |
CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.
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pubmed:affiliation |
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
Comparative Study
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