Linked Life Data

2457761

Source:http://linkedlifedata.com/resource/pubmed/id/2457761

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-9-26
pubmed:abstractText
The sinus node is not only important for the generation of the cardiac impulse but also as conductor of this impulse from the site of origin toward the atrium. An easy method to investigate conduction properties of sinus nodal tissue directly is described. The isolated right atrium of the rabbit was divided--via an incision perpendicular to the crista terminalis--into two halves connected only by a bridge of sinus nodal tissue. By means of two atrial surface electrodes conduction through the sinus node bridge was monitored. It appeared that conduction in the sino-atrial border zone is many times slower than in the atrium and refractory period markedly longer. In the center of the sinus node conduction is again slower and refractory period longer than in the border zone. Validity of the method was tested by reconstruction of the conduction route of stimulated impulses using microelectrode recordings. Applications of the method were demonstrated by studying the effects of rate and rhythm, hypothermia, hypoxia, acetylcholine and norepinephrine as well as verapamil. The model is suitable for investigation of the effects of drugs and other interventions on impulse conduction in sinus nodal tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
667-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
An easy and direct approach to investigate conduction properties of the rabbit sinus node.
pubmed:affiliation
Department of Physiology, University of Limburg, Maastricht, The Netherlands.
pubmed:publicationType
Journal Article, In Vitro