|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1988-10-4
|
|
pubmed:abstractText |
A series of 6-substituted tricyclic ergoline partial structures has been synthesized and found to possess very strong serotonin agonist activity. A methoxy group at the 6-position greatly enhances activity, but at the expense of compound stability. Substituting the 6-position with protophyllic groups that are also electron-withdrawing in character enhances both activity and stability.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1746-53
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:2457705-Animals,
pubmed-meshheading:2457705-Brain,
pubmed-meshheading:2457705-Chemical Phenomena,
pubmed-meshheading:2457705-Chemistry,
pubmed-meshheading:2457705-Corticosterone,
pubmed-meshheading:2457705-Hydroxyindoleacetic Acid,
pubmed-meshheading:2457705-Indoles,
pubmed-meshheading:2457705-Male,
pubmed-meshheading:2457705-Rats,
pubmed-meshheading:2457705-Rats, Inbred Strains,
pubmed-meshheading:2457705-Receptors, Serotonin,
pubmed-meshheading:2457705-Serotonin,
pubmed-meshheading:2457705-Structure-Activity Relationship
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists.
|
|
pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
