Linked Life Data

2456832

Source:http://linkedlifedata.com/resource/pubmed/id/2456832

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-9-15
pubmed:abstractText
To examine biochemical changes in brain substance P (SP) systems associated with development of behavioral sensitization induced by methamphetamine (MAP), regional substance P-like immunoreactivity (SP-LI) and SP receptor binding in the rat brain were measured after acute and long-term MAP administration. Single administration of 8 mg/kg MAP significantly reduced the striatal SP-LI concentration 1 h after the injection. This reduction was blocked by pretreatment with haloperidol. Although repeated administration of 4 mg/kg MAP for 14 consecutive days did not affect the SP-LI concentration in any brain regions including the striatum, it decreased specific SP receptor binding in the striatum and increased those in the frontal cortex. Scatchard analysis of saturation isotherm of specific SP binding revealed that the decreased specific SP binding in the striatum resulted from a decrease in the maximal number (Bmax) of SP receptors and that increased binding in the frontal cortex resulted from an increase in Bmax. These changes in SP receptor binding lasted for at least 7 days. It is emphasized that the persisting changes induced by long-term MAP administration in the SP receptor may contribute to behavioral sensitization to MAP in rats and may be associated with neuronal mechanisms in MAP psychosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
453
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of acute and long-term treatment with methamphetamine on substance P concentration and receptor numbers in the rat brain.
pubmed:affiliation
Department of Neuropsychiatry, Okayama University Medical School, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't