Linked Life Data

2455965

Source:http://linkedlifedata.com/resource/pubmed/id/2455965

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-8-19
pubmed:abstractText
The objective of the studies reported herein was to identify and characterize T cell and B cell recognition sites within the pre-S regions of HBsAg/p39, and to analyze functional T-cell-B cell interactions at the level of in vivo antibody production. The results indicate: (1) several peptides within the pre-S(1) region of HBsAg were identified which can induce and elicit HBsAg/p39-specific T-cell proliferation; (2) a 10 amino acid peptide, p12-21, and the 94-117 sequence define pre-S(1)-specific T-cell recognition sites; (3) five distinct, pre-S(1)-specific antibody binding sites and 2 pre-S(2)-specific antibody binding sites were identified; (4) synthetic pre-S(1) region T-cell determinants can prime in vivo antibody production to multiple B-cell epitopes within the pre-S(2) and S regions, as well as within the pre-S(1) region; and (5) specificity of the primed T cell population can influence the specificity of the B-cell response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
225
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
T-cell recognition of pre-S regions of HBsAg can bypass nonresponse to the S region.
pubmed:affiliation
Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, CA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't