| pubmed-article:2455018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2455018 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:2455018 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2455018 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2455018 | lifeskim:mentions | umls-concept:C0206256 | lld:lifeskim |
| pubmed-article:2455018 | lifeskim:mentions | umls-concept:C2243187 | lld:lifeskim |
| pubmed-article:2455018 | pubmed:dateCreated | 1988-8-2 | lld:pubmed |
| pubmed-article:2455018 | pubmed:abstractText | The effect of interferon (IFN) treatment on the early stages of herpes simplex virus type 1 (HSV-1) replication in three types of human cells was investigated. Interferon pretreatment was shown to reduce the steady state levels of both total and polysomebound HSV-1 immediate early alpha mRNAs. Using the nuclear run-off transcription assay, we showed that IFN selectively inhibited transcription of the HSV-1 genes, with no effect on transcription of total cellular RNA or that of the beta-tubulin RNA. Thus, IFN appears to inhibit the initiation of HSV-1 alpha gene transcription rather than affect the stability of the respective mRNAs. IFN did not prevent the HSV-1-induced early shut-off of host cellular protein synthesis caused by a structural protein of infecting virus. This observation indicated that the IFN-mediated inhibition of HSV-1 replication is at a stage beyond viral penetration into the cytoplasm. These results suggested that IFN blocked HSV-1 replication primarily at a very early stage, during the onset of alpha mRNA transcription. | lld:pubmed |
| pubmed-article:2455018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2455018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2455018 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2455018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2455018 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2455018 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:2455018 | pubmed:author | pubmed-author:PanetAA | lld:pubmed |
| pubmed-article:2455018 | pubmed:author | pubmed-author:ObermanFF | lld:pubmed |
| pubmed-article:2455018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2455018 | pubmed:volume | 69 ( Pt 6) | lld:pubmed |
| pubmed-article:2455018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2455018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2455018 | pubmed:pagination | 1167-77 | lld:pubmed |
| pubmed-article:2455018 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2455018 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2455018 | pubmed:articleTitle | Inhibition of transcription of herpes simplex virus immediate early genes in interferon-treated human cells. | lld:pubmed |
| pubmed-article:2455018 | pubmed:affiliation | Department of Virology, Hebrew University Hadassah Medical School, Jerusalem, Israel. | lld:pubmed |
| pubmed-article:2455018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2455018 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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