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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-8-8
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pubmed:abstractText |
UCHT1, a CD3-producing hybridoma, is lysed by cloned human T cells of both CD4 and CD8 phenotypes. The lysis is specific for the CD3 receptor and is mediated by 90% or more of all T cells from blood, without evidence for a subset of CD4 T cells incapable of cytotoxicity. CD4 clones characterized as 'helper' cells by in vitro help for specific antibody production by B cells also lysed CD3 targets. Varicella zoster virus (VZV) super-infected B lymphoblasts were lysed by three of six VZV-specific T-cell clones and 1 Cl-specific T-cell clones lysed 1 Cl hybridoma targets. Resting B cells (from tonsil) coated with CD3 antibody were lysed by CD4 clones. The data suggest that the majority of clonable CD4+ T cells lyse target cells recognized via CD3 or through the antigen receptor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-2429845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-2950204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-3005647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-3021464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-3160953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-3485254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-3489062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-3491783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-4600315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6181153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6197356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6203977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6205713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6225798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6226584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6333987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6600491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6609990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6788570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6981813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-6991122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2454888-708370
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2454888-Antigens, Viral,
pubmed-meshheading:2454888-B-Lymphocytes,
pubmed-meshheading:2454888-CD4-Positive T-Lymphocytes,
pubmed-meshheading:2454888-Clone Cells,
pubmed-meshheading:2454888-Cytotoxicity, Immunologic,
pubmed-meshheading:2454888-Epitopes,
pubmed-meshheading:2454888-Herpesvirus 3, Human,
pubmed-meshheading:2454888-Humans,
pubmed-meshheading:2454888-Hybridomas,
pubmed-meshheading:2454888-Mitosis,
pubmed-meshheading:2454888-Receptors, Antigen, T-Cell,
pubmed-meshheading:2454888-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1988
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pubmed:articleTitle |
Lysis of CD3 hybridoma targets by cloned human CD4 lymphocytes.
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pubmed:affiliation |
Human Tumour Immunology Group, University College London School of Medicine, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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