Linked Life Data

2454189

Source:http://linkedlifedata.com/resource/pubmed/id/2454189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-7-19
pubmed:abstractText
The cardiac 'pacemaker' current is recorded in isolated sino-atrial node cells during hyperpolarizations at voltages from -40/-50 mV to -100/-110 mV, which corresponds to the range where diastolic depolarization occurs. if is a hyperpolarizing-activated current, carried by Na and K, and in the pacemaker voltage range is inward. These properties allow if to serve as a tool to generate and control the 'pacemaker' depolarization phase of the action potential in sino-atrial node cells. The current if has long been shown to mediate the accelerating action of catecholamines in the heart. More surprisingly, recent experiments show that low doses of acetylcholine exert on if a strong inhibitory action. This new finding modifies the view that the slowing of pacemaker activity caused by acetylcholine is essentially due to activation of a K-current.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0195-668X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8 Suppl L
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The pacemaker current in the sinus node.
pubmed:affiliation
Dipartimento di Fisiologia e Biochimica Generali, Elettrofisiologia, Milano, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't