Linked Life Data

2453946

Source:http://linkedlifedata.com/resource/pubmed/id/2453946

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1988-6-28
pubmed:abstractText
The effect of lindane (gamma-HCH) on temperature, food intake and body weight was studied in male and female rats after single or repeated non-convulsant oral doses. A single dose of 30 mg/kg induced a significant decrease of core temperature (0.4 degrees C in males and 0.66 degrees C in females) 5 h after administration when compared to the control value. Lindane-induced hypothermia was strongly potentiated (1.45 degrees C) by cold stress when rats were kept at 4 degrees C. The same dose of lindane produced a significant decrease in body weight gain (-85% in males and -219% in females compared to the control gain), accompanied by a diminution of food intake, 24 h after administration. No decrease in both parameters was observed when alpha- or delta-HCH isomers 30 mg/kg were tested. After daily administration with 10 mg/kg lindane for 7 days, no hypothermic effects were observed. However, a slight but significant decrease in body weight gain was recorded over the treatment period. This effect was also accompanied by a reduced food intake. The observed stereoselective effects of HCH isomers on core temperature and body weight could be a useful model to study the mechanisms of lindane neurotoxicity at low subconvulsant doses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-94
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The effect of non-convulsant doses of lindane on temperature and body weight.
pubmed:affiliation
Department of Pharmacology and Toxicology, Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't