| pubmed-article:2453925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2453925 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:2453925 | lifeskim:mentions | umls-concept:C0007987 | lld:lifeskim |
| pubmed-article:2453925 | lifeskim:mentions | umls-concept:C0003323 | lld:lifeskim |
| pubmed-article:2453925 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:2453925 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:2453925 | pubmed:issue | 4857 | lld:pubmed |
| pubmed-article:2453925 | pubmed:dateCreated | 1988-7-5 | lld:pubmed |
| pubmed-article:2453925 | pubmed:abstractText | The human immunodeficiency virus type 1 (HIV-1) uses the CD4 protein as a receptor for infection of susceptible cells. A candidate structure for the HIV-1 binding site on the CD4 protein was identified by epitope mapping with a family of eight functionally distinct CD4-specific monoclonal antibodies in conjunction with a panel of large CD4-derived synthetic peptides. All of the seven epitopes that were located reside within two immunoglobulin-like disulfide loops situated between residues 1 and 168 of the CD4 protein. The CD4-specific monoclonal antibody OKT4A, a potent inhibitor of HIV-1 binding, recognized a site between residues 32 and 47 on the CD4 protein. By analogy to other members of the immunoglobulin superfamily of proteins, this particular region has been predicted to exist as a protruding loop. A synthetic analog of this loop (residues 25 to 58) showed a concentration-dependent inhibition of HIV-1-induced cell fusion. It is proposed that a loop extending from residues 37 to 53 of the CD4 protein is a binding site for the AIDS virus. | lld:pubmed |
| pubmed-article:2453925 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2453925 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2453925 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2453925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2453925 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2453925 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:2453925 | pubmed:author | pubmed-author:KentS BSB | lld:pubmed |
| pubmed-article:2453925 | pubmed:author | pubmed-author:HoodL ELE | lld:pubmed |
| pubmed-article:2453925 | pubmed:author | pubmed-author:HahnB HBH | lld:pubmed |
| pubmed-article:2453925 | pubmed:author | pubmed-author:ShawG MGM | lld:pubmed |
| pubmed-article:2453925 | pubmed:author | pubmed-author:TaxR LRL | lld:pubmed |
| pubmed-article:2453925 | pubmed:author | pubmed-author:JamesonB ABA | lld:pubmed |
| pubmed-article:2453925 | pubmed:author | pubmed-author:KongL ILI | lld:pubmed |
| pubmed-article:2453925 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2453925 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:2453925 | pubmed:volume | 240 | lld:pubmed |
| pubmed-article:2453925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2453925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2453925 | pubmed:pagination | 1335-9 | lld:pubmed |
| pubmed-article:2453925 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2453925 | pubmed:meshHeading | pubmed-meshheading:2453925-... | lld:pubmed |
| pubmed-article:2453925 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2453925 | pubmed:articleTitle | Location and chemical synthesis of a binding site for HIV-1 on the CD4 protein. | lld:pubmed |
| pubmed-article:2453925 | pubmed:affiliation | Division of Biology, California Institute of Technology, Pasadena 91125. | lld:pubmed |
| pubmed-article:2453925 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2453925 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2453925 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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