| pubmed-article:2453884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C0035142 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:2453884 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:2453884 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2453884 | pubmed:dateCreated | 1988-7-8 | lld:pubmed |
| pubmed-article:2453884 | pubmed:abstractText | A methodology was developed for stable gene transfer into cloned nontransformed human T lymphocytes. Stable high-level gene expression was achieved in cloned human T cells by using a self-replicating Epstein-Barr virus (EBV) episomal replicon. A comparison of five eukaryotic promoters established that the Rous sarcoma virus 3' long terminal repeat (RSV 3' LTR) and the lymphopapilloma virus (LPV) 5' LTR are optimal for episome-based expression in T cells. Effective (greater than 95%), selective, and reversible anti-sense RNA-mediated gene inhibition of a model T-cell-associated molecule (CD8) was achieved in a cytotoxic human T-cell clone by using an EBV episome-based, RSV 3' LTR-driven expression system. The linking of anti-sense RNA mutagenesis and T-cell cloning technologies should contribute significantly to studies of human T-cell function. | lld:pubmed |
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| pubmed-article:2453884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2453884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2453884 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2453884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2453884 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2453884 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2453884 | pubmed:author | pubmed-author:KaplanD RDR | lld:pubmed |
| pubmed-article:2453884 | pubmed:author | pubmed-author:HamillT WTW | lld:pubmed |
| pubmed-article:2453884 | pubmed:author | pubmed-author:CHUY JYJ | lld:pubmed |
| pubmed-article:2453884 | pubmed:author | pubmed-author:TykocinskiM... | lld:pubmed |
| pubmed-article:2453884 | pubmed:author | pubmed-author:HauerC ACA | lld:pubmed |
| pubmed-article:2453884 | pubmed:author | pubmed-author:GrogerR KRK | lld:pubmed |
| pubmed-article:2453884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2453884 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:2453884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2453884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2453884 | pubmed:pagination | 4010-4 | lld:pubmed |
| pubmed-article:2453884 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2453884 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2453884 | pubmed:articleTitle | Use of an Epstein-Barr virus episomal replicon for anti-sense RNA-mediated gene inhibition in a human cytotoxic T-cell clone. | lld:pubmed |
| pubmed-article:2453884 | pubmed:affiliation | Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106. | lld:pubmed |
| pubmed-article:2453884 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2453884 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2453884 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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