rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
1988-7-14
|
pubmed:abstractText |
Immunoglobulin heavy chain gene antisense transcripts contribute to the expression of translocated c-myc genes in several murine plasma cell tumors. These novel, chimeric transcripts comprise 5-50% of steady-state c-myc mRNA. Two transcripts isolated as cDNA clones use the normal splice donor and acceptor sites within the c-myc first intron. Another cDNA clone has the potential for encoding two types of c-myc proteins. The significance of immunoglobulin heavy chain gene antisense transcripts and transcriptional competence of the immunoglobulin heavy chain locus for c-myc expression is discussed.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0950-9232
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
469-76
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:2453828-Animals,
pubmed-meshheading:2453828-Base Sequence,
pubmed-meshheading:2453828-Gene Expression Regulation,
pubmed-meshheading:2453828-Genes, Immunoglobulin,
pubmed-meshheading:2453828-Genes, Switch,
pubmed-meshheading:2453828-Immunoglobulin Heavy Chains,
pubmed-meshheading:2453828-Immunoglobulin gamma-Chains,
pubmed-meshheading:2453828-Mice,
pubmed-meshheading:2453828-Molecular Sequence Data,
pubmed-meshheading:2453828-Plasmacytoma,
pubmed-meshheading:2453828-Proto-Oncogene Proteins,
pubmed-meshheading:2453828-RNA,
pubmed-meshheading:2453828-RNA, Antisense,
pubmed-meshheading:2453828-RNA, Messenger,
pubmed-meshheading:2453828-RNA, Neoplasm,
pubmed-meshheading:2453828-Transcription, Genetic,
pubmed-meshheading:2453828-Translocation, Genetic
|
pubmed:year |
1988
|
pubmed:articleTitle |
Translocated c-myc genes produce chimeric transcripts containing antisense sequences of the immunoglobulin heavy chain locus in mouse plasmacytomas.
|
pubmed:affiliation |
Department of Biochemistry, State University of New York, Stony Brook 11794-5215.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|