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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1988-6-24
|
| pubmed:abstractText |
Amrinone and trapidile belong to a group of positive inotropic and simultaneously vasodilating substances, whose effects are based on an inhibition of phosphodiesterase (PDE), thus enriching intracellular c-AMP. In neutrophilic granulocytes these PDE-antogonists will produce an inhibition of adherence and phagocytosis, whereas the migration was not affected. The lower leukocyte effective concentration of 10 mmol/l can be achieved by a therapeutical application, so that a slight inhibition of the leukocyte function has to be accounted for as a side effect.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0323-4347
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
760-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2453405-Amrinone,
pubmed-meshheading:2453405-Cell Adhesion,
pubmed-meshheading:2453405-Cell Movement,
pubmed-meshheading:2453405-Cyclic AMP,
pubmed-meshheading:2453405-Humans,
pubmed-meshheading:2453405-Neutrophils,
pubmed-meshheading:2453405-Phagocytosis,
pubmed-meshheading:2453405-Pyrimidines,
pubmed-meshheading:2453405-Trapidil
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
[Effect of amrinone and trapidil on adherence, migration and phagocytic behavior of neutrophilic granulocytes of the human].
|
| pubmed:affiliation |
Institut für Physiologie, Wilhelm-Pieck-Universität Rostock, DDR.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|