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pubmed-article:2452046pubmed:abstractTextThe influence of the detergent dioctyl sodium sulfosuccinate on clearance from the lungs of inhaled technetium-99m-labelled dietylenetriamine pentaacetate (99mTc-DTPA) was studied in twelve rabbits. An aerosol of dioctyl sodium sulfosuccinate or its vehicle alone was administered for 5 min prior to aerosolized 99mTc-DTPA via a bag-in-bottle system. Time-activity curves were obtained from the right lung with a gamma camera. In rabbits given detergent, clearance of 99mTc-DTPA was significantly faster than in rabbits given vehicle alone. No changes were seen in arterial PO2 and compliance. Our data indicates that the transfer of 99mTc-DTPA from alveoli to blood can be accelerated by administration of the detergent dioctyl sodium sulfosuccinate without any dramatic change in surface tension. Clearance of 99mTc-DTPA may be a very sensitive indicator of altered surfactant function.lld:pubmed
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pubmed-article:2452046pubmed:articleTitlePulmonary clearance of inhaled 99mTc-DTPA: effect of the detergent dioctyl sodium sulfosuccinate in aerosol.lld:pubmed
pubmed-article:2452046pubmed:affiliationDepartment of Clinical Physiology, University of Lund, Sweden.lld:pubmed
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