Linked Life Data

2452046

Source:http://linkedlifedata.com/resource/pubmed/id/2452046

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-6-8
pubmed:abstractText
The influence of the detergent dioctyl sodium sulfosuccinate on clearance from the lungs of inhaled technetium-99m-labelled dietylenetriamine pentaacetate (99mTc-DTPA) was studied in twelve rabbits. An aerosol of dioctyl sodium sulfosuccinate or its vehicle alone was administered for 5 min prior to aerosolized 99mTc-DTPA via a bag-in-bottle system. Time-activity curves were obtained from the right lung with a gamma camera. In rabbits given detergent, clearance of 99mTc-DTPA was significantly faster than in rabbits given vehicle alone. No changes were seen in arterial PO2 and compliance. Our data indicates that the transfer of 99mTc-DTPA from alveoli to blood can be accelerated by administration of the detergent dioctyl sodium sulfosuccinate without any dramatic change in surface tension. Clearance of 99mTc-DTPA may be a very sensitive indicator of altered surfactant function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0144-5979
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Pulmonary clearance of inhaled 99mTc-DTPA: effect of the detergent dioctyl sodium sulfosuccinate in aerosol.
pubmed:affiliation
Department of Clinical Physiology, University of Lund, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't