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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1988-5-31
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pubmed:abstractText |
The effects of intranigral injection of dynorphin(1-13), substance P and their combination on striatal dopamine (DA) metabolism as well as circling behavior were studied in rats. Dynorphin(1-13) produced a significant dose-dependent increase of dihydroxyphenyl acetic acid (DOPAC) concentration as well as the number of contralateral circling. No change in dopamine (DA) concentration was observed. Substance P caused a dose-dependent increase of DOPAC concentration. At large doses it also produced an increase in DA concentration. Combined intranigral dynorphin(1-13) and substance P brought about an additive effect for the increase of DOPAC and the number of contralateral circling. No additive effect was found when dynorphin(1-13) and neurokinin A were injected together intranigrally.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
443
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
310-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2451993-Animals,
pubmed-meshheading:2451993-Corpus Striatum,
pubmed-meshheading:2451993-Dopamine,
pubmed-meshheading:2451993-Drug Interactions,
pubmed-meshheading:2451993-Dynorphins,
pubmed-meshheading:2451993-Functional Laterality,
pubmed-meshheading:2451993-Male,
pubmed-meshheading:2451993-Naloxone,
pubmed-meshheading:2451993-Rats,
pubmed-meshheading:2451993-Rats, Inbred Strains,
pubmed-meshheading:2451993-Stereotyped Behavior,
pubmed-meshheading:2451993-Substance P,
pubmed-meshheading:2451993-Substantia Nigra
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pubmed:year |
1988
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pubmed:articleTitle |
Intranigral injection of dynorphin in combination with substance P on striatal dopamine metabolism in the rat.
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pubmed:affiliation |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
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pubmed:publicationType |
Journal Article
|