rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1988-5-26
|
pubmed:abstractText |
The effect of 5, 10, and 20 mg/kg bw cyclosporine on rat endocrine and exocrine pancreatic function was studied. Glucose-dependent insulin secretion from the endocrine pancreas was shown to be significantly impaired 8 days after cyclosporine was given once daily at a dose as low as 5 mg/kg. CCK-8-stimulated amylase and lipase secretion were less sensitive to the noxious effect of cyclosporine being impaired at a dose of 10 mg/kg. Trypsin secretion was shown to be impaired at 20 mg/kg cyclosporine only. Our results demonstrate that cyclosporine causes dose-dependent impairment of both pancreatic endocrine and exocrine functions: the endocrine pancreas being more sensitive to the noxious action than the exocrine pancreas.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0041-1337
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
45
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
698-700
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:2451868-Amylases,
pubmed-meshheading:2451868-Animals,
pubmed-meshheading:2451868-Behavior, Animal,
pubmed-meshheading:2451868-Blood Glucose,
pubmed-meshheading:2451868-Body Weight,
pubmed-meshheading:2451868-Creatinine,
pubmed-meshheading:2451868-Cyclosporins,
pubmed-meshheading:2451868-Insulin,
pubmed-meshheading:2451868-Intubation, Gastrointestinal,
pubmed-meshheading:2451868-Islets of Langerhans,
pubmed-meshheading:2451868-Lipase,
pubmed-meshheading:2451868-Male,
pubmed-meshheading:2451868-Pancreas,
pubmed-meshheading:2451868-Rats,
pubmed-meshheading:2451868-Rats, Inbred Strains,
pubmed-meshheading:2451868-Sincalide,
pubmed-meshheading:2451868-Somatostatin,
pubmed-meshheading:2451868-Trypsin
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pubmed:year |
1988
|
pubmed:articleTitle |
Differential sensitivity of rat exocrine and endocrine pancreas to cyclosporine.
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pubmed:affiliation |
Department of Medicine, University of Essen, Federal Republic of Germany.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|