Linked Life Data

2451786

Source:http://linkedlifedata.com/resource/pubmed/id/2451786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6166
pubmed:dateCreated
1988-5-19
pubmed:abstractText
The p68 protein is a highly conserved nuclear antigen that is thought to be important in the regulation of cell growth and division. It is found in dividing cells of all mammals and amphibians tested, but not in quiescent cells. The protein shows a distinct granular distribution in the nucleus and is induced within four hours of serum stimulation of quiescent mouse fibroblasts. The p68 protein was first identified because of its specific immunological cross-reaction with the DNA tumour virus nuclear oncogene SV40 large T, detected with the anti-SV40 large T monoclonal antibody DL3C4, now renamed PAb204. Sequencing of human complementary DNA coding for the growth-regulated p68 nuclear protein has revealed the molecular basis for its cross-reaction with SV40 large T antigen and its extensive homology with the translation initiation factor eIF-4A. The sequence similarity between p68 and eIF-4A is interesting because eIF-4A acts as an ATP-dependent RNA helicase and T antigen is an ATP-dependent DNA helicase. We suggest that p68 could be a DNA or RNA helicase in the cell nucleus which is involved in replication, transcription or RNA processing and is required for cell growth.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
332
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
736-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Nuclear protein with sequence homology to translation initiation factor eIF-4A.
pubmed:affiliation
Imperial Cancer Research Fund Clare Hall Laboratories, Herts, UK.
pubmed:publicationType
Journal Article