Linked Life Data

2450762

Source:http://linkedlifedata.com/resource/pubmed/id/2450762

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-5-3
pubmed:abstractText
The sodium channel blocker tetrodotoxin partially inhibited [3H]batrachotoxinin-A 20-alpha-benzoate binding to rat brain synaptosomes. This inhibition results from a decrease in the apparent affinity of the radioligand, which indicates that sites 1 and 2 of the sodium channel are not independent as thought previously. Computer-assisted data analysis allowed two binding sites for BTX-B to be distinguished. These sites could be differentiated by means of the divalent cations Mg2+ and Ca2+, that inhibit BTX-B binding completely. Tetrodotoxin diminished the inhibition by Mg2+ and vice versa, suggesting a common mechanism of action for the inhibition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[3H]batrachotoxinin-A 20-alpha-benzoate binding to sodium channels in rat brain: sensitivity to tetrodotoxin and divalent cations.
pubmed:affiliation
Division of Medicinal Chemistry, State University Leiden, The Netherlands.
pubmed:publicationType
Journal Article, In Vitro