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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-4-11
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pubmed:abstractText |
The pS2 gene is transcriptionally induced by oestrogen in the human breast cancer cell line MCF-7. We demonstrate here that the 5' flanking sequences (-3000 to +10 bp) of the pS2 gene possess the properties of an oestrogen-inducible promoter. Interestingly, this oestrogen induction could not be demonstrated in transient transfection assays in MCF-7 cells, but only in stably transformed MCF-7 cells, which suggests that some factors responsible for oestrogen induction may be present in limiting amounts in these cells and absent in HeLa cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
306-13
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2450536-Base Sequence,
pubmed-meshheading:2450536-Breast Neoplasms,
pubmed-meshheading:2450536-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:2450536-Endonucleases,
pubmed-meshheading:2450536-Estrogens,
pubmed-meshheading:2450536-Gene Expression Regulation,
pubmed-meshheading:2450536-Genes,
pubmed-meshheading:2450536-HeLa Cells,
pubmed-meshheading:2450536-Humans,
pubmed-meshheading:2450536-Neoplasm Proteins,
pubmed-meshheading:2450536-Plasmids,
pubmed-meshheading:2450536-Proteins,
pubmed-meshheading:2450536-RNA,
pubmed-meshheading:2450536-Single-Strand Specific DNA and RNA Endonucleases,
pubmed-meshheading:2450536-Transcription, Genetic,
pubmed-meshheading:2450536-Transfection,
pubmed-meshheading:2450536-Tumor Cells, Cultured,
pubmed-meshheading:2450536-Tumor Suppressor Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
The 5' flanking region of the human pS2 gene mediates its transcriptional activation by estrogen in MCF-7 cells.
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pubmed:affiliation |
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Strasbourg, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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