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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1988-4-21
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pubmed:abstractText |
Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic and chronotropic effect. Both effects were completely abolished in atria derived from capsaicin-treated guinea pigs. The positive inotropic and chronotropic effects of NT in guinea pig atria were mimicked by capsaicin and calcitonin gene-related peptide (CGRP). These results were interpreted as an indication that NT produces its cardiovascular effects in guinea pigs by activating capsaicin-sensitive sensory neurons.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1079-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2450340-Acetylcholine,
pubmed-meshheading:2450340-Animals,
pubmed-meshheading:2450340-Atropine,
pubmed-meshheading:2450340-Blood Pressure,
pubmed-meshheading:2450340-Calcitonin Gene-Related Peptide,
pubmed-meshheading:2450340-Capsaicin,
pubmed-meshheading:2450340-Female,
pubmed-meshheading:2450340-Guinea Pigs,
pubmed-meshheading:2450340-Heart Rate,
pubmed-meshheading:2450340-Male,
pubmed-meshheading:2450340-Myocardial Contraction,
pubmed-meshheading:2450340-Neostigmine,
pubmed-meshheading:2450340-Neuropeptides,
pubmed-meshheading:2450340-Neurotensin,
pubmed-meshheading:2450340-Substance P
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pubmed:articleTitle |
Participation of capsaicin-sensitive neurons in the cardiovascular effects of neurotensin in guinea pigs.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, QC Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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