Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-4-14
pubmed:abstractText
1. Effects of a naturally occurring flavonoid, silybin, on histamine release from human basophils were examined, in order to assess the potential utility in the treatment of allergic disorders. 2. The f-met peptide and anti-IgE-induced histamine release was significantly (P less than 0.05) inhibited in a concentration-dependent fashion. Conversely, no significant (P greater than 0.05) effect on calcium ionophore A23187-induced histamine secretion was documented. The inhibitory activity was significantly (P less than 0.05) reversed by elevating extracellular calcium concentrations. 3. The anti-allergic properties of silybin can be reasonably ascribed to a membrane-stabilizing activity, possibly related to an interference in calcium influx. These results indicate that an in vivo evaluation of the anti-allergic activity of silybin would be worthwhile.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-14212116, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-2409013, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-4181251, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-47876, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-49201, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6157344, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6161310, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6166675, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6178414, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6181790, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6186378, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6202731, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6418162, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6661236, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-67562, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-6818414, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-70222, http://linkedlifedata.com/resource/pubmed/commentcorrection/2449903-72118
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
747-52
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of silybin on histamine release from human basophil leucocytes.
pubmed:affiliation
Department of Internal Medicine, University of Milan, Ospedale Maggiore Policlinico, Italy.
pubmed:publicationType
Journal Article, In Vitro