Linked Life Data

2449263

Source:http://linkedlifedata.com/resource/pubmed/id/2449263

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-3-25
pubmed:abstractText
Levels of substance P-like immunoreactivity (SP-LI) of the rat urinary bladder were unaffected up to 1 h from exposure to capsaicin (1 microM) in vitro. A longer (3-6 h) exposure to capsaicin decreased SP-LI by about 40-60% as compared to 10-20% of controls. An analysis of the time course of bladder SP-LI changes following s.c. capsaicin (50 mg/kg) or extrinsic bladder denervation (pelvic ganglionectomy) indicated that at 3 h from capsaicin administration bladder SP-LI was reduced at an extent similar to that observed following in vitro exposure to the drug. These findings provide evidence that the early phase of tissue depletion of sensory neuropeptides following systemic capsaicin desensitization may involve a peripheral site of action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
436
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
402-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Involvement of a peripheral site of action in the early phase of neuropeptide depletion following capsaicin desensitization.
pubmed:affiliation
Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't