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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-3-30
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pubmed:abstractText |
Among several cholesterol oxidation products, 25-hydroxycholesterol is particularly potent in enhancing basic protein-induced carboxyfluorescence leakage from liposomes. Both myelin basic protein and poly(L-arginine) are effective at submicromolar concentrations in stimulating this vesicle rupture. Leakage is greatly augmented by the presence of only 1% of the 25-hydroxycholesterol. The possible relevance of these findings to myelin pathology is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-dielaidoylphosphatidylethanolami...,
http://linkedlifedata.com/resource/pubmed/chemical/25-hydroxycholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/4-carboxyfluorescein,
http://linkedlifedata.com/resource/pubmed/chemical/6-carboxyfluorescein,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Fluoresceins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxycholesterols,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Basic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylcholines,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/polyarginine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
938
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2449243-Cholesterol,
pubmed-meshheading:2449243-Fluoresceins,
pubmed-meshheading:2449243-Humans,
pubmed-meshheading:2449243-Hydroxycholesterols,
pubmed-meshheading:2449243-Liposomes,
pubmed-meshheading:2449243-Myelin Basic Proteins,
pubmed-meshheading:2449243-Peptides,
pubmed-meshheading:2449243-Phosphatidylcholines,
pubmed-meshheading:2449243-Phosphatidylethanolamines,
pubmed-meshheading:2449243-Spectrometry, Fluorescence
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pubmed:year |
1988
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pubmed:articleTitle |
25-Hydroxycholesterol promotes myelin basic protein-induced leakage of phospholipid vesicles.
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pubmed:affiliation |
Department of Biochemistry, McMaster University, Health Sciences Centre, Hamilton, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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