Linked Life Data

2449194

Source:http://linkedlifedata.com/resource/pubmed/id/2449194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8-9
pubmed:dateCreated
1988-3-15
pubmed:abstractText
Spontaneously beating cardiomyocytes of newborn rats were exposed in culture to the gamma globulin fraction from the blood serum of patients with allergic asthma and dilated cardiomyopathy. The gamma globulin fraction of the asthmatics inhibited in a dose-dependent fashion the positive chronotropic response of lactate or pyruvate-treated myocytes to clenbuterol, an adrenergic agonist that acted via stimulation of beta 2 adrenoceptors. The gamma globulin fraction of the cardiomyopathic patients increased the rate of beating. This effect was stereoselectively inhibited by the beta blocker (-)-propranolol, indicating an involvement of beta adrenoceptors. The serum gamma globulin fraction from healthy persons had no effect on the beating rate. The effects of both the asthmatic and cardiomyopathic gamma globulin fractions were abolished by immunoprecipitation with antihuman gamma globulin and antihuman IgG. The chronotropic effects of the gamma globulin fraction may be attributed to the presence of autoantibodies to beta-adrenergic receptors, more specifically beta 2 receptors in the case of the asthmatics and beta 1 receptors in the case of the cardiomyopathic patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-766X
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S634-9
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effects of the serum gamma globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic beta adrenoceptor function in cultured neonatal rat heart myocytes.
pubmed:affiliation
Central Institute for Cardiovascular Research, Academy of Sciences of the GDR, Berlin-Buch.
pubmed:publicationType
Journal Article