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Immunohistochemical findings are reported from an endocrinologically active tumor of the liver hilus in a 39 year old woman. Clinical findings were dominated by difficult to control hypokalemia, cholelithiasis and mild hypoglycemia. Immunohistochemical studies demonstrated somatostatin, beta-HCG and neuron-specific enolase in the tumor cells. No further tumor was found at autopsy. Review of the literature relating to the previously reported tumors of the hepatobiliary system demonstrates great variability in these neoplasms with respect to histologic structure, staining characteristics, ultrastructure, results of immunohistochemical studies and clinical manifestations.
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