Linked Life Data

2448061

Source:http://linkedlifedata.com/resource/pubmed/id/2448061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-3-10
pubmed:abstractText
This paper is the first description of a calcium-activated nonspecific cation channel in adult ventricular muscle. We report gating kinetics and ionic selectivity data from experiments performed at the single channel level. Calcium activation is described by a gating model wherein two ions are involved in the reaction. Channel gating exhibited marked voltage dependence. Ionic selectivity experiments indicated that the channel is cation-selective but unable to discriminate between Na+ and K+. We discuss evidence that this channel mediates transient inward current in ventricular tissue; thus, the channel may be involved in after depolarization-induced cardiac arrhythmias.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0009-7330
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
411-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Reconstitution and characterization of a calcium-activated channel from heart.
pubmed:affiliation
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.