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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1988-3-15
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pubmed:abstractText |
Intracellular recording from CA1 neurons confirmed that short periods of anoxia (95% N2 + 5% CO2 for 2-4 min) have a hyperpolarizing action, caused by a rise in K conductance. After blockage of K channels with extracellular Cs+ and tetraethylammonium (or intracellular Cs+), large inward currents of Ca were evoked by depolarizing pulses: transient currents at a holding potential near -70 mV, and more sustained ones near -50 mV. Both types of Ca current were much reduced or fully suppressed after 1-3 min of anoxia, but they largely (or fully) recovered within 1-10 min of starting reoxygenation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-4212
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2157-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2448022-Animals,
pubmed-meshheading:2448022-Calcium,
pubmed-meshheading:2448022-Cesium,
pubmed-meshheading:2448022-Electric Conductivity,
pubmed-meshheading:2448022-Electrophysiology,
pubmed-meshheading:2448022-Hippocampus,
pubmed-meshheading:2448022-Ion Channels,
pubmed-meshheading:2448022-Neurons,
pubmed-meshheading:2448022-Oxygen,
pubmed-meshheading:2448022-Potassium,
pubmed-meshheading:2448022-Rats,
pubmed-meshheading:2448022-Rats, Inbred Strains,
pubmed-meshheading:2448022-Tetraethylammonium Compounds
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pubmed:year |
1987
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pubmed:articleTitle |
Anoxia reversibly suppresses neuronal calcium currents in rat hippocampal slices.
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pubmed:affiliation |
Anaesthesia Research Department, McGill University, Montréal, Qué., Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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