| pubmed-article:2447115 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2447115 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:2447115 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:2447115 | lifeskim:mentions | umls-concept:C0032019 | lld:lifeskim |
| pubmed-article:2447115 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2447115 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:2447115 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:2447115 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:2447115 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2447115 | pubmed:dateCreated | 1988-2-2 | lld:pubmed |
| pubmed-article:2447115 | pubmed:abstractText | Glycoprotein hormone and/or subunit secretion has been increasingly recognized in patients with pituitary nonsecretory adenomas and alpha-subunit secretion has been reported to occur in 5-10% of all pituitary tumors. We investigated the dopaminergic regulation of alpha-subunit secretion in four patients with alpha-subunit secreting pituitary adenomas documented by serum and immunocytochemical studies. In three of the four patients there was a significant decrease in serum alpha-subunit concentrations during 6 weeks of bromocriptine administration. Tumor size decreased in two patients. In pituitary tumor cells from one patient cultured in vitro, dopamine caused a highly significant decrease in media alpha-subunit concentrations. To investigate whether dopaminergic regulation of alpha-subunit secretion occurs at a pre- or posttranslational level, messenger RNA (mRNA) from cultured tumor cells from one patient was analyzed by Northern blot techniques. A decrease in alpha-subunit mRNA occurred in cells incubated with 10(-10), 10(-8), and 10(-6) M dopamine. We conclude that dopamine suppressed pituitary tumor alpha-subunit secretion and mRNA levels. Dopamine agonists may be of benefit in the therapy of patients with such tumors. | lld:pubmed |
| pubmed-article:2447115 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2447115 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2447115 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2447115 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2447115 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2447115 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2447115 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2447115 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2447115 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2447115 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2447115 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2447115 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2447115 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:2447115 | pubmed:author | pubmed-author:ZervasN TNT | lld:pubmed |
| pubmed-article:2447115 | pubmed:author | pubmed-author:BlackP MPM | lld:pubmed |
| pubmed-article:2447115 | pubmed:author | pubmed-author:KlimanBB | lld:pubmed |
| pubmed-article:2447115 | pubmed:author | pubmed-author:ShupnikM AMA | lld:pubmed |
| pubmed-article:2447115 | pubmed:author | pubmed-author:KlibanskiAA | lld:pubmed |
| pubmed-article:2447115 | pubmed:author | pubmed-author:BikkalH AHA | lld:pubmed |
| pubmed-article:2447115 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2447115 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:2447115 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2447115 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2447115 | pubmed:pagination | 96-102 | lld:pubmed |
| pubmed-article:2447115 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2447115 | pubmed:meshHeading | pubmed-meshheading:2447115-... | lld:pubmed |
| pubmed-article:2447115 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2447115 | pubmed:articleTitle | Dopaminergic regulation of alpha-subunit secretion and messenger ribonucleic acid levels in alpha-secreting pituitary tumors. | lld:pubmed |
| pubmed-article:2447115 | pubmed:affiliation | Thyroid Unit, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:2447115 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2447115 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2447115 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2447115 | lld:pubmed |
