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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-2-2
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pubmed:abstractText |
Glycoprotein hormone and/or subunit secretion has been increasingly recognized in patients with pituitary nonsecretory adenomas and alpha-subunit secretion has been reported to occur in 5-10% of all pituitary tumors. We investigated the dopaminergic regulation of alpha-subunit secretion in four patients with alpha-subunit secreting pituitary adenomas documented by serum and immunocytochemical studies. In three of the four patients there was a significant decrease in serum alpha-subunit concentrations during 6 weeks of bromocriptine administration. Tumor size decreased in two patients. In pituitary tumor cells from one patient cultured in vitro, dopamine caused a highly significant decrease in media alpha-subunit concentrations. To investigate whether dopaminergic regulation of alpha-subunit secretion occurs at a pre- or posttranslational level, messenger RNA (mRNA) from cultured tumor cells from one patient was analyzed by Northern blot techniques. A decrease in alpha-subunit mRNA occurred in cells incubated with 10(-10), 10(-8), and 10(-6) M dopamine. We conclude that dopamine suppressed pituitary tumor alpha-subunit secretion and mRNA levels. Dopamine agonists may be of benefit in the therapy of patients with such tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bromocriptine,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoprotein Hormones, alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Hormones, Anterior,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin-Releasing Hormone
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-972X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-102
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2447115-Adenoma,
pubmed-meshheading:2447115-Adult,
pubmed-meshheading:2447115-Aged,
pubmed-meshheading:2447115-Bromocriptine,
pubmed-meshheading:2447115-Dopamine,
pubmed-meshheading:2447115-Female,
pubmed-meshheading:2447115-Glycoprotein Hormones, alpha Subunit,
pubmed-meshheading:2447115-Gonadotropin-Releasing Hormone,
pubmed-meshheading:2447115-Histocytochemistry,
pubmed-meshheading:2447115-Humans,
pubmed-meshheading:2447115-Immunoenzyme Techniques,
pubmed-meshheading:2447115-Male,
pubmed-meshheading:2447115-Middle Aged,
pubmed-meshheading:2447115-Pituitary Hormones, Anterior,
pubmed-meshheading:2447115-Pituitary Neoplasms,
pubmed-meshheading:2447115-RNA, Messenger,
pubmed-meshheading:2447115-RNA, Neoplasm,
pubmed-meshheading:2447115-Thyrotropin-Releasing Hormone,
pubmed-meshheading:2447115-Tumor Cells, Cultured
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pubmed:year |
1988
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pubmed:articleTitle |
Dopaminergic regulation of alpha-subunit secretion and messenger ribonucleic acid levels in alpha-secreting pituitary tumors.
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pubmed:affiliation |
Thyroid Unit, Massachusetts General Hospital, Boston 02114.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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