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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1988-2-2
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pubmed:abstractText |
Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. GAL had an ED50 of 2 nM for the inhibition. The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. These data suggest a possible neuromodulator role of GAL in the human urinary bladder.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
143
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2446889-Aged,
pubmed-meshheading:2446889-Atropine,
pubmed-meshheading:2446889-Electric Stimulation,
pubmed-meshheading:2446889-Female,
pubmed-meshheading:2446889-Galanin,
pubmed-meshheading:2446889-Humans,
pubmed-meshheading:2446889-Male,
pubmed-meshheading:2446889-Middle Aged,
pubmed-meshheading:2446889-Muscle Contraction,
pubmed-meshheading:2446889-Peptides,
pubmed-meshheading:2446889-Potassium Chloride,
pubmed-meshheading:2446889-Synaptic Transmission,
pubmed-meshheading:2446889-Urinary Bladder
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pubmed:year |
1987
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pubmed:articleTitle |
Galanin: a potent modulator of excitatory neurotransmission in the human urinary bladder.
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pubmed:affiliation |
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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