Linked Life Data

2446493

Source:http://linkedlifedata.com/resource/pubmed/id/2446493

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1987-12-23
pubmed:abstractText
Twelve cases of pure ovarian teratoma were studied by immunohistochemical methods to determine the incidence and localization of alpha-fetoprotein (AFP) production. There were six mature teratomas (grade 0) and six immature ones (grades 1-3). Three tumors (grades 1, 3, and 3 and stages III, I, and III, respectively) had isolated foci of AFP immunoreactivity in yolk-sac-like vesicles, intestinal-type epithelium, or tissue resembling liver, whereas the other nine tumors had no AFP-positive components. The former three patients had preoperative serum AFP determinations; the values were elevated in two of them, and in both instances the oncofetoantigen became undetectable one month after oophorectomy. Both patients are alive and well 15 and 25 months later; the third patient with a normal serum AFP before surgery and a positively stained tumor died of recurrent disease. The authors' findings indicate that the production of AFP in pure ovarian teratomas recapitulates its pattern of synthesis during ontogeny. Furthermore, it is suggested that a preoperative elevation of serum AFP in a pure ovarian teratoma does not seem to correlate with stage or grade, beyond minimizing the possibility that the tumor is grade 0, or mature.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9173
pubmed:author
pubmed:issnType
Print
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
713-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Alpha-fetoprotein localization in pure ovarian teratoma. An immunohistochemical study of 12 cases.
pubmed:affiliation
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School and Hospital, Minneapolis.
pubmed:publicationType
Journal Article