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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1988-1-12
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pubmed:abstractText |
Cell-mediated immune response to nucleocapsid determinants, including HBcAg and HBeAg, are important in the clearance of HBV-infected hepatocytes. This process is modulated by interferon and humoral responses to these antigens. Antibodies to the envelope proteins contribute to protective immunity, but the relative importance of pre-S and S determinants in evoking a response and the relative contributions of these antibodies in virus neutralization remains unclear. It is known, however, that antibodies binding to the RFHBs1 epitope on the HBs sequence 124-137 are capable of protecting against further infection and are present in convalescent subjects and in recipients of the plasma-derived and recombinant hepatitis B vaccines. Detailed analysis of the specificity of the anti-HBs response in vaccinees shows it to be qualitatively similar to that seen during recovery from natural infection.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins
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pubmed:status |
MEDLINE
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pubmed:issn |
0032-5473
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
63 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-6
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pubmed:dateRevised |
2009-10-22
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pubmed:meshHeading |
pubmed-meshheading:2446303-Animals,
pubmed-meshheading:2446303-Antibodies, Monoclonal,
pubmed-meshheading:2446303-Capsid,
pubmed-meshheading:2446303-Epitopes,
pubmed-meshheading:2446303-Hepatitis B,
pubmed-meshheading:2446303-Hepatitis B Antibodies,
pubmed-meshheading:2446303-Hepatitis B virus,
pubmed-meshheading:2446303-Humans,
pubmed-meshheading:2446303-Immunity, Cellular,
pubmed-meshheading:2446303-Vaccination,
pubmed-meshheading:2446303-Viral Core Proteins,
pubmed-meshheading:2446303-Viral Envelope Proteins
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pubmed:year |
1987
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pubmed:articleTitle |
The immune response to hepatitis B virus.
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pubmed:affiliation |
Department of Academic Medicine, Royal Free Hospital, London, UK.
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pubmed:publicationType |
Journal Article,
Review
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