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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1988-1-21
|
| pubmed:abstractText |
Our views of interferon production and action have evolved from the simple to the complex. We review evidence that interferon-gamma (IFN-gamma) may induce a portion of its antiviral activity through the induction of another interferon. This is shown by demonstrating IFN-alpha in the supernatant fluids of IFN-gamma-treated mouse cells and showing that, under certain conditions, the antiviral activity of IFN-gamma in mouse and human cells can be reduced by antibody to IFN-alpha or IFN-beta, respectively. Induction of mouse spleen, bone marrow, and peritoneal exudate cells also results in their production of IFNs-alpha and/or -beta. In addition, new preliminary data indirectly suggests the presence of IFN-gamma in poly(IC):poly(LC)-treated mouse cells. In both of these systems, the maximal antiviral activity appears to develop as a consequence of the induction of a second interferon.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0197-8357
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
603-14
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1987
|
| pubmed:articleTitle |
Do the interferons act singly or in combination?
|
| pubmed:affiliation |
Department of Microbiology, University of Texas Medical School, Galveston 77550.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|