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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1988-1-7
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pubmed:abstractText |
FK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O. The compound suppressed immune responses in vitro and in vivo with mice. This immunosuppressive effect was more potent than that of ciclosporin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1249-55
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2445721-Animals,
pubmed-meshheading:2445721-Antibody Formation,
pubmed-meshheading:2445721-Chemistry, Physical,
pubmed-meshheading:2445721-Cyclosporins,
pubmed-meshheading:2445721-Female,
pubmed-meshheading:2445721-Fermentation,
pubmed-meshheading:2445721-Graft vs Host Disease,
pubmed-meshheading:2445721-Immunity, Cellular,
pubmed-meshheading:2445721-Immunosuppressive Agents,
pubmed-meshheading:2445721-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:2445721-Mice,
pubmed-meshheading:2445721-Mice, Inbred BALB C,
pubmed-meshheading:2445721-Mice, Inbred C57BL,
pubmed-meshheading:2445721-Physicochemical Phenomena,
pubmed-meshheading:2445721-Prednisolone,
pubmed-meshheading:2445721-Pyridines,
pubmed-meshheading:2445721-Streptomyces,
pubmed-meshheading:2445721-Tacrolimus
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pubmed:year |
1987
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pubmed:articleTitle |
FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.
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pubmed:affiliation |
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
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pubmed:publicationType |
Journal Article
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